Rat Bite Fever Essay -- streptobacillus moniliformis, rna

One of the main bowel movements of the disease known as Rat flake Fever is from infection by the bacteria Streptobacillus moniliformis. This bacterium is commonly the cause of the disease in North America (Elliot, 2007). This disease is typically troublesome to diagnose, leading to a delay in treatment and unnecessary enlarge in the severity of its symptoms. Cases of rat bite fever are kinda rare in North America, and those resulting in death are withal less common, making the study of its patho componentsis difficult. In order to wear out arrest this disease, work is being done to annotate the genome of the bacterium. Gene annotation is a process in which biological information is attached to a sensation gene or genomic sequence. Oftentimes, this is initially done automatically via computer analysis, and hence later is manually annotated. That is the case here, where an automatic annotation has been performed for many of the genes at bottom the S. moniliformis geno me (Nolan, 2009), but it is necessary to manually annotate the genome in order to better understand the biological processes. The manual annotation includes identifying or confirming the genes role in coding, gene expression, biochemical function, and many another(prenominal) functions (Stein, 2001).Smon_0852 & Smon_0853Smon_0852 is annotated as a Polynucleotide adenylyltransferase region, which is involved in the biological process, RNA processing, and its molecular(a) function is ATP binding, RNA binding, hydrolase activity, and nucleotidyl transferase, according to GO. Pfam identifies that Smon_0852 is a part of the Protein domains Poly A polymerase head and Nudix family. The Poly A polymerase head domain is involved in adding the poly (A) backside to mRNA (Cao, 1992). The Nudix family is ... ...l structure of NGO0477 from Neisseria gonorrhoeae reveals a novel protein fold incorporating a helix-turn-helix motif. Proteins 781798-1802(2010).Stein, L. (2001). Genome annotatio n from sequence to biology. Nature Reviews Genetics 2 (7) 493503.doi10.1038/35080529. PMID 11433356.Tscherne, J.S., Nurse, K., Popienick, P., Michel, H., Sochacki, M. and Ofengand, J. Purification, cloning, and moving picture of the 16S RNA m5C967 methyltransferase from Escherichia coli. Biochemistry 3818841892(1999). Yau, K. Cyclic Nucleotide-gated Channels an expanding new family of ion channels Proc Natl Acad Sci USA. 91(9) 34813483 (1994).Zhang H, Huang K, Li Z, Banerjei L, Fisher KE, Grishin NV, Eisenstein E, Herzberg O, Crystal structure of YbaK protein from Haemophilus influenzae (HI1434) at 1.8 A resolution utilitarian implications. Proteins 4086-97(2000).